Aaron C. Logan, MD, PhD, MPhil
(redacted) · Sunnyvale, CA · 94086
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Biographical Data
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Birthdate: August 24, 1974
Place of Birth: Reno, Nevada
Marital status: Married
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Education
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2006
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Doctor of Medicine, with Highest Distinction
Keck School of Medicine, University of Southern California
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2004
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Doctor of Philosophy (Molecular Microbiology and Immunology)
Keck School of Medicine, University of Southern California
Dissertation: Leukemia cell vaccine generation using lentiviral vectors.
Advisor: Donald B. Kohn, MD
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1997
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Master of Philosophy (History of Medicine)
University of Cambridge, England
Thesis: Cardiac transplantation 1967-1987: Public opinion, the media, and the development of a clinical therapy.
Advisors: Andrew Cunningham, DPhil, and Harmke Kamminga, DPhil
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1995
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Bachelor of Science, Summa cum laude
University of Nevada, Reno (Honors Program)
Major: Pre-medicine; Minor: Psychology
Thesis: Euthanasia in Western Culture.
Advisors: Francis X. Hartigan, PhD and Gregory Hayes, MD
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1991
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Honors Diploma
Edward C. Reed High School, Sparks, NV
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Training
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2008-
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Fellow, Hematology and Blood and Marrow Transplantation
Stanford University Hospital
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2006-2008
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Intern and Resident, Internal Medicine
Stanford University Hospital
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Honors and Awards
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American Society of Hematology Abstract Award, 2011
American Society of Hematology Research Training Award for Fellows, 2011
American Society of Blood and Marrow Transplantation Clinical Research Training Fellow, 2010
Graduation with Highest Distinction, Keck School of Medicine, 2006
University of Southern California Order of Arete, 2006
Dean's Recognition, Junior-Senior Continuum, 2006
Alpha Omega Alpha, 2005
American Society of Gene Therapy Travel Award, 2004
Medical Student Research Forum Oral Presentation Award, 2003
Keck School of Medicine Outstanding Teaching in Year II Award, 2003
USC Award for Excellence in Teaching in Cell and Neurobiology, 2003
American Society of Gene Therapy Travel Award, 2002
Medical Student Research Forum First Place Poster Award, 2002
Children's Hospital Los Angeles Poster Forum Best Poster Award, 2001
Medical Student Research Forum First Place Poster Award, 2001
Medical Student Research Forum Oral Presentation Award, 1999
USC School of Medicine Dean's Scholar Award, 1998
Summa cum laude, University of Nevada, Reno 1995
University of Nevada, Reno President's Gold Medal Award, 1995
Senior Scholar Award, 1995
Inducted into Phi Kappa Phi Honor Society, 1995
All-American Scholar Award, 1994, 1996
Golden Key National Honor Society Junior Scholar Award, 1993
Inducted into Golden Key National Honor Society, 1993
University of Nevada, Reno Dean's List, 1993, 1994, 1995
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Teaching Experience
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Resident/Fellow Hematology didactic sessions, 2009-present—Provided lectures in diverse hematology subject matter to Internal Medicine residents and Hematology-Oncology fellows.
Teaching Assistant, Microscopic Anatomy, 2001-2004, 2005-2006—Directed small group discussions amongst 25-50 medical students, organized and presented review materials, assisted with writing exam questions.
STD Educator, Community Outreach Program, 1998-1999—Taught high school students about the risks and consequences of unprotected sexual activities.
Microanatomy Tutor, Medical Scholars Program, 1998-1999—Led discussions amongst groups of 10-30 first year medical students about medical histology, created handouts and practice questions for students.
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Publications
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Logan AC, Gao H, Wang C, Sahaf B, Jones CD, Marshall EL, Buno I, Armstrong RA, Fire AZ, Weinberg KI, Mindrinos M, Zehnder JL, Boyd SD, Xiao W, and Miklos DB. (2011). High-throughput VDJ sequencing for chronic lymphocytic leukemia minimal residual disease and immune reconstitution assessment. Proc Natl Acad Sci USA 108(52):21194-21199. [Pubmed]
Logan, AC, Yank, V, and Stafford, RS. (2011). Off-Label Use of Recombinant Factor VIIa in U.S. Hospitals: Analysis of Hospital Records. Ann Int Med 154:516-522. [Pubmed]
Yank, V, Tuohy, CV, Logan, AC, Bravata, DM, Staudenmayer, K, Eisenhut, R, Sundaram, V, McMahon, D, Stave, CD, Olkin, I, McDonald, KM, Owens, DK, Stafford, RS. (2011). Systematic Review: Benefits and Harms of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications. Ann Int Med 154:529-540. [Pubmed]
Logan, AC and Goodnough, LT. (2010). Recombinant factor VIIa: An assessment of evidence regarding efficacy and safety in the off-label setting. Hematology Am Soc Hematol Educ Program 2010; 153-159. [Pubmed]
Yank, V, Tuohy, CV, Logan, AC, Bravata, DM, Staudenmayer, K, Eisenhut, R, Sundaram, V, McMahon, D, Stave, CD, Olkin, I, McDonald, KM, Owens, DK, Stafford, RS. (2010). Comparative effectiveness of recombinant factor VIIa for off-label indications versus usual care. Comparative effectiveness review. (Prepared by Stanford-UCSF Evidence-based Practice Center under Contract No #290-02-0017) Rockville, MD: Agency for Healthcare Research and Quality. May 2010.
Kohrt, H, Logan, A, Temmins, C, Witteles, R, Liedtke, M, and Medeiros, B. (2008). Reversible high-output cardiac failure, an unusual marker of disease status in multiple myeloma. Leuk Lymphoma 49(3):581-585.
Logan, AC, Nightingale, SJ, Haas, DL, Cho, GJ, Pepper, KA, and Kohn, DB. (2004). Factors influencing the titer and infectivity of lentiviral vectors. Hum Gene Ther 15(10):976-988.  (PDF)
Logan, AC, Haas, DL, Kafri, T, and Kohn, DB. (2004). Self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration. J Virol 78(16):8421-8436. (PDF)
Haas, DL, Lutzko, C, Logan, AC, Cho, GJ, Skelton, D, Yu, XJ, Pepper, KA, and Kohn, DB. (2003). The Moloney murine leukemia virus repressor binding site represses expression in murine and human hematopoietic stem cells. J Virol 77(17):9439-9450. (PDF)
Logan, AC, Lutzko, C, and Kohn, DB. (2002). Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Curr Opin Biotechnol 13(5):429-436. (PDF)
Abstracts and Presentations
Logan AC, Vashi N, Faham M, Carlton V, Buno I, Zheng J, Moorhead M, Klinger M, Willis M, Waqar A, Zehnder JL, and Miklos DB. (2011). Massively parallel immunoglobulin gene sequencing provides ultra-sensitive minimal residual disease detection and predicts post-transplant relapse in acute lymphoblastic leukemia by three to six months. Presented at ASH 2011.
Logan AC, Faham M, Carlton V, Zheng J, Moorhead M, Willis T, Jones CD, Zhang MB, Waqar AN, Zehnder JL, and Miklos DB. (2011). High-throughput immunoglobulin gene sequencing quantifies minimal residual disease in CLL with 10e-6 sensitivity and strongly predicts relapse after allogeneic hematopoietic cell transplantation. Presented at ASH 2011.
Alimoghaddam, K, Logan, AC, Wong, R, Weiss, S, Fontaine, M, Arai, S, Grumet, C, and Miklos, DB. (2011). Minor ABO mismatch is associated with increased non-relapse mortality after allogeneic hematopoietic cell transplantation. Presented at the 2011 BMT Tandem Meeting in Honolulu, HI.
Logan AC, Wang C, Sahaf B, Jones CD, Marshall EL, Buno I, Fire AZ, Mindrinos M, Zehnder JL, Boyd SD, and Miklos DB. (2010). High-throughput VDJ sequencing is superior to quantitative PCR and flow cytometry for the quantification of minimal residual disease in chronic lymphocytic leukemia after hematopoietic cell transplantation. Blood 116:1290.
Logan, AC, Turnbull, BB, Lavori, PW, Miklos, DB, Negrin, RS, Lowsky, R, and Kohrt, HE. (2010). Assessment of the utility of subset donor chimerism for predicting event-free survival after non-myeloablative allogeneic hematopoietic cell transplantation using TLI and ATG. Biol Blood Marrow Transplant 16(2):S272.
Logan, AC, Yank, V, and Stafford, RS. (2009). Off-label use of recombinant factor VIIa in Unites States Hospitals: 2000-2008. Blood 114(11):67.
Yank, V, Logan, AC, Tuohy, CV, Bravata, DM, Staudenmayer, K, Eisenhut, R, Sundaram, V, McMahon, D, McDonald, KM, Owens, D, and Stafford, RS. (2009). Comparison of thromboembolic event rates in randomized controlled trials and observational studies of recombinant factor VIIa for off-label indications. Blood 114(11):1403.
Logan, AC, Su, R, George, TI, Kohrt, HE, Medeiros, BC, and Alizadeh, AA. (2009). High risk of early mortality in adult patients with acquired hemophagocytic lymphohistiocytosis. Blood 114(11):1359.
Yank, V, Tuohy, CV, Logan, AC, Bravata, DM, Staudenmayer, K, Eisenhut, R, Sundaram, V, McMahon, D, Olkin, I, McDonald, KM, Owens, DK, and Stafford, RS. (2009). The safety and efficacy of recombinant activated factor VIIa for cardiac surgery: patterns of use and comparative effectiveness review. Abstract 5057, 31st Annual Meeting of the Society for Medical Decision Making.
Yank, V, Tuohy, CV, Logan, AC, Bravata, DM, Staudenmayer, K, Eisenhut, R, Sundaram, V, McMahon, D, Olkin, I, McDonald, KM, Owens, DK, and Stafford, RS. (2009). The safety and efficacy of recombinant activated factor VIIa for non-traumatic intracranial hemorrhage: patterns of use and comparative effectiveness review. Abstract 5039, 31st Annual Meeting of the Society for Medical Decision Making.
Yank, V, Tuohy, CV, Logan, AC, Bravata, DM, Staudenmayer, K, Eisenhut, R, Sundaram, V, McMahon, D, Olkin, I, McDonald, KM, Owens, DK, and Stafford, RS. (2009). The safety and efficacy of recombinant activated factor VIIa for traumatic bleeding: patterns of use and comparative effectiveness review. Abstract 5035, 31st Annual Meeting of the Society for Medical Decision Making.
Wei, K, Logan, AC, Wakelee, H, Simon, MC, and Kuo, C. (2008). Systemic VEGF inhibition induces hepatic Epo production and erythrocytosis via HIF-2alpha-dependent and -independent mechanisms. Blood 112(11):482.
Logan, AC, Kohrt, HE, Krupitskaya, Y, Pereira, I, and Berube, C. (2007). Pancytopenia in a patient with end-stage renal disease and systemic lupus erythematosus. Presented at the American College of Physicians All-California Scientific Meeting in Monterey, CA.
Logan, AC, Nijmeh, J, Eng, J, and Levitt, L. (2006). Pericardial effusion in a patient with agnogenic myeloid metaplasia. Presented at the American College of Physicians All-California Scientific Meeting in Monterey, CA.
Logan, AC, Haas, DL, Kafri, T, and Kohn, DB. (2004). Self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration. Mol Ther 9(1):S4. Presented at the 7th annual meeting of the American Society of Gene Therapy in Minneapolis, MN.
Oldenburg, J, Logan, AC, Barcova, M, Ngiam, C, and Cannon, PM. (2004). Improved lentiviral vector system with enhanced safety features. Mol Ther 9(1):S28.
Logan, AC, Haas, DL, and Kohn, DB. (2003). Self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration. Presented at the 2nd annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases in Sonoma, CA.
Logan, AC, and Kohn, DB. (2002). Optimization of HIV-1 based lentiviral vectors for gene-modification of leukemia cells. Mol Ther 5(5):S426. Presented at the 5th annual meeting of the American Society of Gene Therapy in Boston, MA.
Logan, AC, and Kohn, DB. (2002). Self-inactivating lentiviral vectors exhibit residual promoter activity in the enhancer- and TATA box-deleted long terminal repeat. Mol Ther 5(5):S29. Presented at the 5th annual meeting of the American Society of Gene Therapy in Boston, MA.
Logan, AC, Xia, L, Liu, J, and Douvas, A. (2000). Identification of antibodies to the envelope protein of caprine arthritis-encephalitis virus in humans with occupational exposure to goats. J Investig Med 48(1):70A. Presented at the 28th annual Western Student Medical Research Forum in Carmel, CA.
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Academic Service
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Medical Student Research Committee, 2001-2003, 2005
Dean's Recognition Selection Committee, 2002-2004
Norris Cancer Center Student/Post-doc Grand Rounds Steering Committee, 2002-2003
Educational Policy Committee (invited position), 1999-2000
Educational Policy Committee (elected position), 1998-1999
Co-President, Internal Medicine Interest Group, 1998-1999
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Professional Affiliations
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American Association for the Advancement of Science, student member
American Society of Gene Therapy, student member
American Medical Association, student member
American College of Internal Medicine, student member
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Scholarships and Research Support
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Teaching Assistantship, 2001-2004, 2005-2006
National Research Service Award (CA-09569-13), Department of Health and Human Services, 2001
Research Assistantship, 2000-2004
National Research Service Award (AI-07078-18), Department of Health and Human Services, 1999
USC Summer Research Fellowship, 1998, 2000, 2001, 2002
USC Med Best Scholarship, 1998
University of Nevada, Reno Summer Tuition Scholarship, 1994
Golden Key National Honor Society Junior Scholarship, 1993
Dr. Francis Reed Scholarship, 1993
University of Nevada, Reno Freshman Scholarship, 1991
Principal's Scholarship, 1991
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